The potential functional implications of the variation in these genes are currently unknown.
Future plans include increased integration of additional annotation data that assess the functional implications of the variation, including but not limited to intersection of SNP locations with known or predicted functional elements such as splice sites, promoter elements, and polyadenylation sites or overlap with regions of evolutionary conservation, such as provided by the PhastCons scores (21).
To get an impression from the clinical implications of the variation in SCr values on CKD staging, we classified the patients according to the K/DOQI guidelines and evaluated the differences in CKD staging when SCr values were measured by Jaffe or the enzymatic methods [ 18].
In contrast to the lack of knowledge about implications of the variation in exon 4, the variable sites in ECL3 and 4 have been shown to be determinants for virus entry or to modulate virus interaction [ 22, 40, 57, 59, 60].
Nor is there sufficient knowledge on the implications of these variations for the health of the environment and its ecosystems.
We show the effect of varying different parameters on the positions of the turning points in parameter space, and discuss the practical implications of these variations in qualitative behaviour for the design and operation of such a system.
What are the implications of these variations for population exposure?
However, because the CNV analysis does not distinguish between genes and pseudogenes, and there is an RBMY pseudogene located at 9,148,467 9,162,451 (which contains only a single probe and thus does not permit reliable CNV measurement), the biological implication of the variation detected remains uncertain.
