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The importance of lysine acetylation is well appreciated in the context of nuclear histone modifications (Strahl and Allis, 2000), but the regulatory implications of the modification extend beyond gene regulation.
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These results have important implications for the modification of programmes for targeting sustainable behaviour change which is more likely to reduce the impact of future floods.
While the structural implications of this modification on these interactions is understood to some extent for p53 [ 13, 59, 60, 62, 63] little is known about p63 and p73.
Consequently, our finding that the pattern and level of glutathiolation of nuclear proteins change during the cell cycle [24] and with the depletion of nuclear GSH could contribute to the possible implication of this modification in the control of chromatin structure dynamics (for review see [62]).
The functional implications of these modifications are not clearly defined yet; however, an increasing number of investigations suggest two possible roles.
Intense investigation into the role of post-translational modifications, specifically phosphorylation and acetylation, has now begun, driven by the potential implications of these modifications in Alzheimer's disease (AD) and other tauopathies [ 4, 11, 16, 18, 19].
We can use equation 10 with one small change to describe the implications of effect modification of the risk difference by group.
The implication of these modifications for the establishment of durable resistance to inhibitors of cellulose remains to be shown.
Broader implications concern the modification of individual differences in personality variables via their interaction with key information processing targets.
The utility of the model to explore biological implications of Wnt pathway modification and the role of the OCY in bone remodeling was demonstrated.
Further studies are indicated to evaluate the implications of this potential modification of keratoplasty surgery.
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implications of the alterations
outcome of the modification
implications of the changed
implications of the changing
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