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These results augment and refine previous conclusions about the ecological implications of the genetic architecture of quantitative traits, emphasizing a role of adaptive accuracy.
In the current study, we investigated the susceptibility and prognostic implications of the genetic variation in CXCR2 in breast carcinoma.
Efforts to know the implications of the genetic diversity of this bacterium have led to some interesting discoveries relating to its co-evolution with the human host, microevolution during infection and quasi-species development.
The present study is the first report on the implications of the genetic variation in the human HMGB1 gene in a population of critically ill patients admitted to an ICU with SIRS and sepsis.
When the prognostic implications of the genetic aberrations were separately examined in HR+ and HR- tumors, a combination of mutations and gain of PIK3CA, a combined aberration of the PI3K pathway genes, and gain of FOXA1, CDH3, BIRC5, MYBL2, and AIB1 indicated worse RFS rates only in patients with a HR+ tumor (Table 4).
This can only be provided when a consumer/patient has received sufficient relevant information about the genetic test in such a manner that they are able to understand the risks, benefits, limitations and implications of the genetic test, whose consequences may be indirect and long term.
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Implications of the different genetic findings for genetic counselling and genetic testing at present will be described.
A critical issue related to implication of the genetic alteration in the familial disease is whether the heterozygous loss-of-function COQ6 displays haploinsufficiency.
These results provide a useful basis for counselling of women with a family history of breast cancer, and they have implications for the genetic basis of the disease.
A diagnosis of monogenic diabetes also has implications for the genetic testing of other family members.
Our results have implications for the genetic epidemiology of BRCA1.
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