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Further, we evaluated the clinical implications of the alterations in this ratio.
The potential implications of the alterations observed with aging deserve consideration.
Alterations in gene expression for the pyruvate oxidase may be related to culturing statuses, such as nutrition, oxygen dissolved in media, and temperature, as well as interaction with mammalian cells; however, the functional implications of the alterations are unknown.
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We also discuss the implications of these alterations on the neurobiology of HD and the potential to result in hypothalamic, circadian, and sleep pathologies.
We also discuss the implications of these alterations in the context of HIV-1 infection and in light of current concepts of TCR signal transduction.
We consider the implications of these alterations, as well as the distinction between schizophrenia and depression, in the context of novel mGluR5 based therapeutics.
The implications of these alterations for memory function in the illness remain poorly understood.
The implications of these alterations to neutrophil function are discussed within the context of vaccine and novel immune therapy design.
Of note, there were also distinct changes in the regulation of genes coding for enzymes in the pyrimidine and nicotinamide metabolism; however, more work will be required to fully understand the implications of these alterations for UVB-induced senescence.
Although the functional implications of these alterations have not been established fully, such changes may be expected to contribute to altered stromal cell function and the generation of a permissive tumor microenvironment.
Although the in vivo implications of these alterations in MOMP are still unknown, some of them were previously shown to prevent recognition and neutralization by host antibodies in vitro [7], [8], [27].
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