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The Obama administration apparently spent months considering the legal implications of targeting Anwar al-Awlaki, the American citizen who was killed in Yemen last month after being accused of being a terrorist organizer.
In this mini-review, we detail the role of HIF-1α and HIF-2α in intestinal inflammation and injury and therapeutic implications of targeting HIF signaling in IBD.
Finally we discuss the potential therapeutic implications of targeting the functional interaction between ∆F508-CFTR and Dab2.
This review focus on the impact of PTPR alterations across a spectrum of cancers and the clinical implications of targeting PTPRs therein.
We excluded trials focusing on high-risk groups or prevention of psychosis because of the possible ethical implications of targeting interventions at these individuals.
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We have illustrated the implication of targeting hub nodes and proposed network-based drug targets which would cause less side effect.
Although many researchers have reported the clinical implication of targeting CSC surface markers, the fact that the ovarian CSC phenotype was not a consistent state but a changeable state depending on external conditions has been overlooked [ 36].
Regarding the clinical implication of targeting the RAC1 pathway in NSCLC therapy, it has been reported that overexpression of RAC1 is often detected in NSCLC specimens and that there is an association between RAC1 expression with TNM stage and lymph node metastasis of NSCLC.
These findings have potential important therapeutic implications in terms of targeting this signalling axis in human fibrotic lung disease.
Here, we present the current available methodologies to measure HER family receptors and discuss the clinical implications of target quantification.
The implications of cartels targeting anonymous hackers are clearly troubling: attempting to kill faceless voices from the internet demonstrates just how dedicated they are to bullying anyone brave enough to speak out into submission.
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Justyna Jupowicz-Kozak
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