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Although both CAC and AAC scores have been shown to be strong predictors of subsequent cardiovascular morbidity and mortality (1, 2), only a few studies have investigated the association of calcium progression with future events (3, 4), and there is less certainty about the implications of progression of vascular calcification (5).
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5 Implications of disease progression include restrictions in daily activities, reduced work productivity, and diminished quality of life.
Because of the clinical implications of JSN progression for disability and work impairment, protection from the onset or worsening of JSN should be an important factor when choosing between therapeutic modalities.
We enrolled disease-free patients in order to exclude bother related to adjuvant and salvage therapies and avert the social/emotional implication of disease progression.
Moreover, we excluded from our study both adjuvant-related bother and social/emotional implication of disease progression and obtain health-related HRQOL results with minimal biases.
One implication of this progression model is that RB1− / − retinoblastomas are likely to have a single cell of origin, rather than different origins for the now unlikely different subtypes.
Implications of the buckling progression for composite cylinder applications are described including the finding that composites perform poorly relative to steel on the metric of buckling due to lower density and axial stiffness; composites perform well on the metric of lock-up length when friction is considered.
Such plasticity has implications in progression of breast carcinoma to metastasis, and will likely influence response to therapy.
Design of CRPC trials is still strongly debated 26 and therefore the implications of altering the disease progression criterion were evaluated.
Our data indicate that plasma determination of fibrinogen and C-RP might have a clinical implication in defining the process of progression of PAD in T2D population.
The implications of this behaviour for disease progression and the expression of autoantibodies will become apparent when we study the full one-clone model.
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