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Understanding the underlying implications of mutant TET2 lacking function and its role in myeloid malignancies is a current research priority.
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The clear implication of mutant ras in maintaining the transformed nature of HT1080scc2 was confirmed when these cells were microinjected with the pan ras neutralising antibody Y13-259, which resulted in the morphological detransformation of these cells to a phenotype resembling that of the HT10801c clone.
In addition, we have also performed a more complete analysis of the substrate concentration dependence of the 5D mutant of 4p-PTEN lipid phosphatase activity, and these results fortify the interpretation of the regulatory implications of this mutant.
RNA viruses are notorious for rapidly generating genetically diverse populations during a single replication cycle, and the implications of this mutant population, often referred to as quasispecies, can be vast.
We concur that the implications of SPOP mutant cancers as a target for PARP inhibition is potentially important.
SS: And they're clearly unfazed by the ethical implications of consuming this mutant dish.
In order to assess the long term implications of this, the mutant and parental strain were subjected to starvation survival experiments over a period of 3 weeks (Fig. 2B).
Future population dynamics studies should consider the implications of the intracellular expansion of mutant phenotypes.
This study suggests a crucial function for wild-type huntingtin that cannot be fulfilled by the mutant protein and, thus, these results could have important implications for therapies that aim to reduce levels of mutant huntingtin.
Evidence for the importance of autophagy in the degradation of mutant, misfolded proteins has wide therapeutic implications in the treatment of proteinopathies.
The parent-to-offspring transmission of mutant SCN1A alleles highlighted the clinical implications of genome-wide identification of pSNMs in genetic counseling.
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