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This review summarizes new insights in the pathophysiologic implications of inflammation and microvascular alterations in organ dysfunction, as well as genetic factor contribution, from clinical and experimental studies that were published in 2010 in Critical Care in the fields of multiple organ dysfunction and sepsis.
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Implication of inflammation in pathogenesis of FSGS has been found in some studies [ 29, 30].
With accumulating evidences about the implication of inflammation in the pathogenesis of diseases, the immunoregulatory features of stem cells have drawn more attention.
The association of PTGS2 polymorphism with colorectal cancer points towards the implication of inflammation as an important mediator in the carcinogenesis of these tumours.
In sum, clinical evidence for the implication of inflammation in the development of myocardial hypertrophy and diastolic dysfunction is sparse, although experimental studies suggest a role especially for lymphocytes and macrophages.
The cyclooxygenase-2 (COX-2)/prostaglandin E2 pathway in hypoxic cancer cells has important implications for stimulation of inflammation and tumorigenesis.
This study was designed to determine the implications of small airways inflammation in the development of airflow limitation in smokers by our newly explored method.
These findings have implications for the role of inflammation in cancer progression.
Prolongation of neutrophil life span may have important implications in delayed resolution of inflammation.
Indeed, recent studies emphasize that reprogramming of Th differentiation may have important therapeutic implications for the treatment of inflammation [ 32, 33].
We report that these changes occurred prior to overt signs of symmetrical inflammation and hypothesize that the reported plasticity has important implications for the spread of inflammation in this model and may mirror changes seen in man.
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