Using both in vitro and in vivo models we investigated the implication of immune regulatory cytokines and of subsets of regulatory lymphocytes in the protective effect of TLR2, TLR3, TLR4 and TLR7 agonists.
The clinical implication of immune dysregulation with age is yet to be determined.
The implication of immune responsiveness and cytokine secretion have been found to be widely different depending on the WAT site studied [ 11], which severely limits the actual significance of the conclusions derived from the analysis of data from a single WAT site.
Overall, the implications of such immune phenomena associated with senescence are that susceptibility to specific health conditions may vary with age, with immune impairment eventually leading to increased risk of mortality [ 12– 16].
We detail how influenza viruses evade the host innate immunity, with particular emphasis on the IFNα/β response, and the implications of this immune evasion in pandemic influenza.
Herein, we discuss the potential implications of innate immune ontogeny for the activity of adjuvants contained in licensed infant vaccines, as well as future directions for rational design of adjuvanted vaccines for this age group.
152 There are potential implications of mucosal immune activation for sensorimotor dysfunction of patients with IBS.
36, 37 The aim of this study was to evaluate the clinicopathological impact of BTLA as well as the clinical implications of tumor‐infiltrating immune cells in patients with GBC to assess their potential as new targets for cancer immunotherapy.
Since the discovery that the immune system can control cancer progression, which has been conceptualized in the "three Es" theory [ 1] for "elimination, equilibrium, and escape," supporting the implications of the immune system in the control and selection of tumor cells, scientists and clinicians have tried to exploit this phenomenon to induce an antitumor immune response in cancer patients.
