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To determine the clinical implications of high-risk signatures in addition to its prognostic value, we also carefully evaluated its impact on chemotherapeutic response.
The identification of genes and gene products correlating with prognosis might have therapeutic implications for further differentiation of high risk GIST in the adjuvant setting.
Moreover, experiencing repeated unintended pregnancies suggests increased exposure to unprotected sexual intercourse, which has health implications for HIV-positive individuals in terms of high risk of re-infection with another strain of the virus.
These findings may have implications in the understanding of gliomagenesis, development of targeted therapy and selection of high risk cancer patients for adjuvant therapy.
The implication is that different types of intervention might be required to deal with the two types of high risk prescribing.
Implications of this high risk environment have not been systematically explored.
The major clinical implication of our results is that the disease management program probably does not reach a considerable amount of higher risk patients.
"High-protein diets that contain lots of red meat and high-fat dairy products have implications of higher cholesterol, higher risk of heart disease," says Jessica Fanzo, the Bloomberg Distinguished Associate Professor of Global Food & Agricultural Policy and Ethics at the Berman Institute.
These findings may have implications for the design of high-risk cohorts for PD.
Our findings carry several potential implications including early identification of high-risk patients that would require early and aggressive management in the ICU, as well as prevention and detection of secondary complications.
17– 21 Whether different types of AF have different associations with renal function also remains unclear, and may have potential clinical implications for the management of high-risk patients.
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