Sentence examples for implications of genetic variants from inspiring English sources

Researchers investigating the potential functional implications of genetic variants have often tended to ignore splicing effects [5], although, recently, there have been several large-scale studies to identify common genetic variants with an effect on mRNA splicing [4], [8], [9], [10], [11], [12], [13], [14], [15].

If genotyping for low penetrance risk variants is ever to be implemented as a cost-effective public health strategy, it will be important to understand the implications of genetic variants on tumour biology and treatment options as well as for risk across the entire population.

Besides a strong association of GCA with genes that lie within the major histocompatibility complex (MHC) [ 16- 21], many other studies have shown the implication of genetic variants in key components of immune and inflammatory pathways in GCA susceptibility or clinical expression of this vasculitis [ 21- 34].

The present study examined the implication of genetic variants in the NgR gene and its signaling co-factors (p75 and TROY) and genes encoding for its downstream signaling molecules (WNK1 and Myt1l), in an Australian Caucasian schizophrenia case control population, taking early life adversities into consideration.

It would also be impossible to describe the potential consequences of genomic analyses, because the implications of the majority of genetic variants found to date are not known.

In particular, the interpretation of genetic variants and their implication in disease is one of the major challenges in personalized medicine [ 4- 6].

To study de novo genetic events in cloned animals can help understand formation mechanisms of genetic variants and their biological implications.

Since cloned animals share almost identical genetic background like MZ twins, to study their de novo genetic events can help understand formation mechanisms of genetic variants and their biological implications.

Finally, the identification of genetic variants influencing ANM has potential implications for the treatment of infertile women.

The purpose of this study was to assess the incidence of genetic variants in these receptors and its potential clinical implications in colorectal cancer (CRC).

Because a broad variety of drugs used in clinical practice are organic cations, the existence of genetic variants in the SLC22A1 gene has relevant clinical implications in human pharmacology.