Our findings indicate the implication of alterations in NGFR and NGFR genes in schizophrenia, particularly, in defects of synaptic plasticity.
Our findings indicate the implication of alterations in genes encoding NGF and its receptor in pathogenesis of schizophrenia, particularly, in defects of synaptic plasticity detected in this disorder.
At a more integrated level, the implication of alterations of pathways involved in immune/inflammatory activities and coagulation (see Figure 3) is consistent with the known effects of smoking on risk for inflammatory related diseases and stroke [ 1, 15].
Further support for the clinical implication of alterations in the IRE IRP network is provided by the expression of ferroportin – the major or only iron exporter from cells – which can be altered upon loss of its 5′ IRE, as seen in polycythaemic mice (Ref. 92).
The implications of these alterations for memory function in the illness remain poorly understood.
The implications of these alterations to neutrophil function are discussed within the context of vaccine and novel immune therapy design.
We also discuss the implications of these alterations on the neurobiology of HD and the potential to result in hypothalamic, circadian, and sleep pathologies.
This review summarizes H1 abnormalities in cancer identified by various approaches and critically discusses functional implications of such alterations, as well as potential mechanisms through which they may contribute to the disease.
In this review, we briefly recap the definition of heterogeneity and concept of epigenetics, highlight the potential roles and mechanisms of epigenetic regulation in heterogeneity of lung cancer, and summarize the diagnostic and therapeutic implications of epigenetic alterations in lung cancer, especially the role of DNA methylation and histone acetylation.
