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A third consideration is that the moral/ethical implications of administering a drug with unknown efficacy/safety, for unlicensed indications.
Because there is a lack of large, comparative studies examining the systemic effects of anti-VEGF therapies, understanding the implications of administering these agents in individuals with diabetes is important information for the clinician.
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For instance, a multi-country randomised control trial found that widely accepted practice of administering corticosteroids after head injury could be harmful [ 69] with implications for both policy and practice on this topic.
This study compares the welfare implication of privatization of the distribution networks by comparing two extreme cases, a pure regional distributional monopoly case and a representative pure "free" consumer case, with a benchmark case of administered price regulation.
The objective of this study was to determine whether there was a drug interaction with pharmacokinetic or safety implications between ritonavir, administered at doses used for pharmacokinetic boosting, and fixed dose PA in healthy subjects.
Finally, we discuss the clinical implications of co-suspension delivery technology for developing combination drug therapies administered by pMDIs.
The clinical implications of our results remain unclear; however, our findings suggest that the orally administered combination of lafutidine 10 mg preceded by mosapride 5 mg tablets may be suitable for on-demand treatment in patients with GERD.
We conclude with a discussion of the practical implications of this line of research for those who design and administer selection processes.
A disadvantage of the A&SQ is that it is administered to adults, so cannot be used to assess the implications of amblyopia and/or its treatment from the child's perspective.
However, the potential clinical implications of our studies will depend on whether or not AFMC can be safely administered to patients in high enough doses to be pharmacologically active.
To examine the implications of cortical changes to the neurocognitive performance in the psychosis and bipolar subjects, a trained research psychologist administered standardised tests as part of a broader battery (described previously) (Hermens et al. 2010a, b, 2011).
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