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In clinical trials, poor adherence makes it difficult to draw conclusions about the implications of a trial or treatment, as results may be dose-dependent or rely heavily on a strict adherence to a prescribed regimen [ 1, 3- 5, 8].
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Findings suggest that future protocols for clinical trial recruitment in emergency care should acknowledge the ethical implications of broaching a trial in urgent or emergency care and outline how parents should only be approached when it is judged by the practitioner as being ethically viable to do so [ 50].
Consider the implications of a drug trial in which 100 patients taking a new drug and 100 patients taking a placebo are reported as successful because 25 drug takers improved compared with 10 controls.
Secondly, it enables comparison of trials that use a similar approach with one another, rather than putting all acupuncture trials together as if they were all the same (that is, comparing like with like), both in discussions of the implications of a single trial in relation to others and within a systematic review.
Consequently, PFS may be a better candidate surrogate since the specificity of included 'events' has implications for the power of a trial, the likelihood of a significant result, and ability to conduct cross-trial comparisons [ 18].
The study design, implications of the trial, and alternative options were explained to the subjects in a cover letter.
And even if his testimony in this trial does kill his own presidential chances, he could still carry a lot of influence when the ANC decides next year who will succeed President Thabo Mbeki in 2009.However, the implications of the trial go beyond Mr Zuma's political fate.
The implications of this trial are explored in regards to the potential for sparing inflammation in islets and thus allowing the functioning beta cells to recover and produce more insulin.
I was devastated by Trayvon's [killing], as well as the implications of the trial and the verdict [on] the value of Trayvon's humanity.
Finally, the implications of the trial for efficient provision of ECMO services in the UK will be considered.
Within two weeks, the research assistant contacts the patient to explain the aim and implications of the trial again.
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