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This commentary reviews the context of SCD in the U.S.; describes the framework, measures, and technology infrastructure already created for the HLC; reports on the early experience of teams; highlights the initiative's challenges and opportunities; and reflects on its implications in the setting of health reform.
The data contribute to our understanding of clinical tolerance acquisition in humans with consequent potential therapeutic implications in the setting of allergy and other disease.
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We also reviewed all similar cases from Europe reported in the literature, and we discuss the implications of leishmaniasis in the setting of anti-TNF therapy, which is associated with increased risk for opportunistic infections (1 ).
Several studies have investigated the clinical implication of PTPRs in the setting of cancer treatment.
These issues underline the importance of understanding the effects of hypercapnia on the immune response, and the implications of these effects in the setting of sepsis.
The implications of increased H2O2 production in the setting of CO poisoning and treatment is an important question as it is not clear if this is pathological or due to increased cellular messaging.
This study has important implications for public health, especially in the setting of post-disaster community reconstruction.
The first portion of this paper is a narrative review of the physiologic implications of anemia, hemodilution, and transfusion in the setting of brain-injury and stroke.
The policy and practical implications of this work are profound, particularly in the setting of burgeoning obesity prevalence and the NCD epidemic confronting many Asia-Pacific nations.
We now also understand the timing of occurrence of these genetic events in pancreatic carcinogenesis and progression, and the implications of this information for targeted therapies in the setting of personalized medicine.
Like many women since the Women's Health Initiative study, several participants were fearful of the health implications of taking hormone replacement therapy, particularly in the setting of multiple health conditions and a known family history of cancer [ 57].
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