PDCD4 has been widely studied as anti-cancer therapeutic target [ Lankat-Buttgereit and Goke, 2009]; its role however as a translation inhibitor in inflammation, cell invasion and smooth muscle contraction could be indicative of its implication in the expression of the asthmatic phenotype.
If DNA methylation and chromatin states are broadly maintained following the duplication of a region then this is likely to have implications for the expression of genes in close proximity to the new duplicon.
A more recent study has identified an association between microRNA expression signatures and the different RIP-Tag2 tumorigenesis stages, with the implication that alterations in the expression of these miRNAs could be playing a role in driving these "switches" [16].
To confirm the implication of IKKα in the expression of genes induced by the canonical NF-κB pathway, the deletion of IKKα was tested on S. flexneri-induced IL-8 expression.
This in turn has implications on the expression of other mRNAs and regulatory networks normally targeted by the respective miRNA [123].
Further studies are warranted to assign specific roles to the different galanin receptors in the modulation of the tumour phenotype and to identify the clinical implications of the expression of galanin in NT.
The results have general implications for the expression of bacterial virulence in insects and for the maintenance of both beneficial and disease-associated bacteria in social insects.
To determine the functional implications of the changes in the expression of GABAAR- α1 subunits, we infused muscimol, a GABA R agonist, into the contralesional cortex for a week after the injury.
Trypanosoma brucei is an excellent model system in which to analyze nuclear spatial implications in the regulation of gene expression because the two main surface-protein genes (procyclin and VSG) are transcribed by the highly compartmentalized RNA polymerase I and undergo distinct transcriptional activation or downregulation during developmental differentiation.
The critical time-window for effective repression by glucocorticoids may have interesting implications in the control of CRH expression in vivo.
