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These observations, coupled with the efficacy of contemporary medical therapies in reducing clinical event rates, have important implications for trial design of future human in vivo evaluations of vulnerable coronary plaque.
We conclude that almost one out of 20 placebo treated patients discontinued treatment due to AEs, indicating a significant nocebo in trials for depression treatment adversely affecting adherence and efficacy of current treatments in clinical practice, with additional implications for trial designing.
Although effects were not related to a change in outcome (mortality), learning curves in clinical research may have important safety, ethical, research quality and economic implications for trial conduct.
85 The choice of control interventions has important implications for trial ethics, recruitment, results, and interpretation.
This would have important implications for trial design and interpretation of results.
Our findings also have implications for trial design and patient care.
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Differences in the proportions of ε4 carriers and noncarriers could also have specific implications for trials of antiamyloid therapies because noncarrier participants may more frequently fail to demonstrate amyloid burden when studied with amyloid imaging [ 51].
Reports that some participants wore wristbands inappropriately, and/or delayed completion of trial paperwork could represent confounding variables and have implications for the trial results, and the design of clinical trials within the field of cancer.
Massacesi, C. et al. PI3K inhibitors as new cancer therapeutics: implications for clinical trial design.
Implications for clinical trial design and the interpretation of such studies are discussed.
The findings of these studies and their implications for future trial design are considered.
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