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A choice between experiments based on siRNA pools or multiple individual duplexes has considerable implications for throughput, reagent requirements and data analysis in genome-wide surveys, yet there are relatively few data that directly compare the efficiency of the two approaches.
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This has implications for high-throughput measurements because the time prior to elution of the first analyte is essentially wasted and the overall duty cycle is reduced.
The ability to rapidly inject a sample without interrupting an ongoing separation has implications for high-throughput analyses because the otherwise wasted time prior to elution of the first peak can be effectively utilized.
In nature, the macromolecular organization of multienzyme complexes has important implications for the specificity, controllability, and throughput of multi-step biochemical reaction cascades.
The large number of reads allowed an in-depth analysis of errors, and we found that PCR-induced errors composed the vast majority of non-organism derived species variants, an observation that has significant implications for sequence clustering of similar high-throughput data.
This situation hampers general GC-MS capabilities, and in particular has implications for the development of robust, high-throughput GC-MS analytical protocols required in metabolic profiling and biomarker discovery.
The implications for fragment-based drug discovery and high throughput screening are discussed.
Their locations are small by restaurant standards, and the vertically arranged cubbies, Friedberg said, are far more efficient than horizontal counters, making them excellent for "throughput".
Our findings have important implications for integrating hPSC-derived atrial CMs into high-throughput screenings for selection and validation of lead compounds during early stages of drug discovery.
The results have implications for the identification of promising liposome compositions via high-throughput screening methodologies, as well as the design and optimization of high-throughput reactors for liposome production.
The novel high-throughput KIR genotyping method we developed has implications for many species, including potential application in humans, and the approach could be adapted for other polymorphic immune loci.
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