In this article, we will look at the insights clinical research has provided into such hypoglycemia unawareness, how the clinical and laboratory research data have influenced our understanding and management of problematic hypoglycemia in those with diabetes, and the implications of the basic science for future diabetes management.
Understanding the interactions between ion channels and blockers remains an important goal that has implications for delineating the basic mechanisms of ion channel function and for the discovery and development of ion channel directed drugs.
Thus, acceptance and understanding of evolution has implications for the most basic and vital aspects of our life, food and health, and increasingly, global impact.
The identification of conserved genetic factors necessary for exercise to produce physiological changes in the fly system will have implications, not only for the basic biology of aging and exercise physiology, but will coincidentally identify potential therapeutic targets that may allow the benefits of exercise to be provided to patients unable to exercise, due to injury or pathology.
Accurate models of antigen processing have implications for the study of basic immunology as well as for the design of peptide-based vaccines and other immunotherapies.
The variety in the modes of interaction between the Meis, Pbx and Hox proteins when the presence of a hexapeptide is varied is also of widespread interest, not just for the evolutionary implications highlighted in this manuscript, but also for the basic mechanistic implications for these transcription factors.
The present extracorporeal bowel model system represents a novel tool for the analysis of the underlying molecular mechanisms as well as for the therapy of IBD; thus, the system has implications for both basic researchers and clinicians.
The importance of the role of ribosomal dysfunction in the pathogenesis of hematologic disorders is becoming clearer, and elucidation of the underlying mechanisms could have broad implications for both basic cellular biology and clinical intervention strategies.
The extent of genetic mosaicism has tremendous implications for both basic research and clinical applications.
