Since Shb is a signaling protein participating in angiogenic responses, this finding has implications for choosing an appropriate strategy for inhibiting tumor expansion by anti-angiogenic treatment without simultaneously increasing tumor metastasis.
Our study has important implications for the design of a clinically relevant therapeutic approach for inhibiting MYC in highly aggressive and chemoresistant cancers, such as TNBC, for which no targeted therapy is available.
Moreover, because our results constitute the first analysis of the role of DOHH in mammals, they have significant implications for targeted therapies aimed at inhibiting this enzyme.
Our delineation of the rules of engagement for TAM signaling therefore has important implications for the therapeutic application of inhibiting and activating TAM modulators, particularly with respect to their target specificity and the avoidance of possible treatment side effects in the immune, visual, and reproductive systems.
Implications for understanding factors that could inhibit or enhance community capacity for project development are discussed.
This is a new concept for ectopic mineralization diseases, such as generalized arterial calcification of infancy and pseudoxanthoma elasticum, and has implications for bisphosphonate treatments that both inhibit progression of calcifications but also have known inhibitory effects against osteoclasts.
This relationship between plasma glucose concentration and the percent of glucose reabsorption that is inhibited has important implications for understanding normal renal physiology with respect to glucose handling.
These new data additionally have important implications for therapeutic strategies that target and inhibit telomerase activity in more advanced human cancers, given that initial attempts to combat various cancer types using telomerase inhibitors have suffered some setbacks (Williams, 2013).
The finding could have important implications for the treatment of human GACI: bisphosphonates might inhibit further mineralization but could also elicit an undesirable side effect by inhibiting the regression of soft tissue calcifications through inhibition of osteoclast function.
The findings have theoretical implications for understanding the mechanisms underlying a failure to inhibit unwanted intrusions and clinical implications for disorders involving high levels of intrusive thoughts and memories.
