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This piece of basic biology soon turned out to have important implications for aging and cancer.
It is well known that changes in Ins/Igf signaling have important implications for aging.
Thus, these molecular data that link insulin/insulin growth factor-1 and -2 (Ins/Igf) signaling to the proliferation state of VSELs have implications for aging and senescence.
As NPC segregation and turnover have direct implications for aging studies (Kaeberlein 2010), this and related topics will doubtless be areas of intensive future investigation.
Loss of telomerase function results in progressive telomere shortening and chromosomal instability, which ends up having implications for aging and cancer (Blasco et al., 1997).
This has important implications for aging oocytes [ 8, 9], where cohesin deterioration will induce sister kinetochore biorientation and compromise MCC production, leading to chromosome missegregation and aneuploid fetuses.
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But the findings have important implications for ageing societies faced with a dementia time bomb.
This review will summarize recent findings concerning the relationships between feeding regimens, circadian rhythms, and metabolism with implications for ageing attenuation and life span extension.
A crucial implication for aging oocytes is that cohesin deterioration compromises the SAC in two ways: by promoting sister kinetochore biorientation and by impairing efficient MCC production at kinetochores that have not come under tension, thereby leading to meiosis I chromosome segregation errors such as those underlying trisomy 21 or Down's syndrome.
These findings have important implications for understanding aging and age-related diseases.
This has implications not only for aging, but also for the early detection of diseases involving misfolded proteins.
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CEO of Professional Science Editing for Scientists @ prosciediting.com