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Consequently, our finding that the pattern and level of glutathiolation of nuclear proteins change during the cell cycle [24] and with the depletion of nuclear GSH could contribute to the possible implication of this modification in the control of chromatin structure dynamics (for review see [62]).
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While the structural implications of this modification on these interactions is understood to some extent for p53 [ 13, 59, 60, 62, 63] little is known about p63 and p73.
Regarding the controller structure, the main implication of introducing this modification lies in the fact that it states the possibility of implementing a control law for a general class of models for this kind of motors.
The implication of this change is exciting.
The implication of these modifications for the establishment of durable resistance to inhibitors of cellulose remains to be shown.
Acknowledgements: Thank you to Nicholas Warren, Ph.D. candidate in the Program in Experimental and Molecular Medicine at Dartmouth College, for his commentary on the implications of this epigenetic modification.
Further studies are indicated to evaluate the implications of this potential modification of keratoplasty surgery.
The importance of lysine acetylation is well appreciated in the context of nuclear histone modifications (Strahl and Allis, 2000), but the regulatory implications of the modification extend beyond gene regulation.
The functional implications of these modifications are not clearly defined yet; however, an increasing number of investigations suggest two possible roles.
Intense investigation into the role of post-translational modifications, specifically phosphorylation and acetylation, has now begun, driven by the potential implications of these modifications in Alzheimer's disease (AD) and other tauopathies [ 4, 11, 16, 18, 19].
Further research is required to understand the implication of Col II modification by HNE and other ECM components in OA as well as the potential of HNE-trapping drugs in OA.
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