Sentence examples for implication of these mutations from inspiring English sources

We discuss here known mechanisms of oncogenesis and the clinical implication of these mutations.

As functional consequences on RAS protein could be different of codons 12 and 13 mutations, the clinical implication of these mutations remained unclear until recently [ 6, 18].

A recent breakthrough in our understanding of the pathogenesis of NB is the identification of activating point mutations in the tyrosine kinase domain of the ALK gene as the main cause of familial NB, and implication of these mutations in a substantial fraction of sporadic NB tumors [ 59- 63].

The implications of these mutations are discussed using a structural model of the XPD protein.

To study the structural and functional implications of these mutations on RING2-REP domain of Parkin, we studied the solvent accessibility (SASA/RSA), hydrophobicity, intra-molecular hydrogen bonding profile and domain analysis by various computational tools.

Further investigation is warranted as to the functional implications of these mutations in carcinogenesis.

The prognostic implications of these mutations were highly subgroup-specific.

Here, we have summarized the PSEN2 mutations and the potential implications of these mutations in dementia-associated disorders.

Although the implications of these mutations are provocative, it was unclear whether the mutations would impair the function of the resultant proteins.

There is also limited knowledge of the implications of these mutations with regard to development of severe hemolytic disease in the United States population.

The frequency and clinical impact of PIK3CA mutations need to be assessed in homogeneous biological subgroups of breast cancers, as the prevalence and biological implications of these mutations appear to vary in the different subgroups [ 13, 14, 31].