Our data are in agreement with the literature data concerning the role and implication of these molecules in CC [ 44- 46].
Supplementation of these lipids in Smpdl3b knockdown cells reverted their hyper-inflammatory phenotype, thus confirming an implication of these molecules in the regulation of TLR signaling.
However, further studies are still needed to fully elucidate the clinical implication of these molecules in the mechanisms leading to accelerated atherosclerosis in AS and the benefits of the assessment of these molecules in the daily clinical practice.
Since the first reports on chemokine function, much information has been generated on the implications of these molecules in numerous physiological and pathological processes, as well as on the signaling events activated through their binding to receptors.
In P. fluorescens, the porin OprF is the major outer membrane protein and implication of this molecule in adhesion to living cells [32], matrix protein [33], and abiotic surfaces [34] has already been demonstrated.
Thus it seemed interesting to look into the implication of this molecule during equine colic, during which, release of free radicals seems to be involved [ 1, 5].
Interestingly, there was a significant overlap in the distribution of these cell-cycle proteins between grades (e.g., Aurora A and Plk1 levels, Supplementary Figure 2), which has important implications for exploitation of these molecules as predictors of therapeutic response to cell-cycle-phase-specific mechanistic agents (see Discussion).
Indeed, the implication of matrix molecules contribution to EMT was evident even from early studies [ 87].
In addition, we compared MGMT related parameters with those of volumetry in order to observe possible implications of this molecule in tumor development and, subsequently, treatment response.
17 Although it has not been carefully studied, differences in properties such as heparin binding are observed among the different isoforms, and there could potentially be diverse biological functions of these molecules, and the implications of this for angiogenesis are not yet understood.
