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Authors' response We have clarified the sections about "testing" and "implication" of the hypothesis.
85 Instead we tested an implication of the hypothesis in two randomised trials.
A further critical implication of the hypothesis H1 is that therapeutic drugs should directly or indirectly stimulate lactate production by astrocytes.
A key implication of the hypothesis is that helicases, like the lymphoid-specific helicase and alpha thalassemia/mental retardation syndrome X-linked helicase, passively promote accurate maintenance of DNA methylation by preventing the sequestration of DNMTs at sites of unrepaired non-B DNA structure.
In support of this implication of the hypothesis, numerous studies have found reduced brain volume in people with ADHD, particularly prefrontal cortex, cerebellum, corpus callosum, and basal ganglia, areas of the brain engaged in information processing and planning/selecting the appropriate behavioural response [ 102, 103, 147, 270].
According to the opinions of this reviewer (see below) and reviewer 1, in the part "Implication of the hypothesis", I have extended the discussion to some other representative hypotheses (the section " A comparison with other hypotheses on the origin of translation").
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The implication of this hypothesis lies on the findings of the distinct activity and specificity of the same enzyme in organisms as well as plant species [ 22, 25, 29]; an example includes varied activities of starch branching enzyme isoforms between dicotyledon and monocotyledon plants (reviewed in [ 28]).
Others needed to be tested experimentally by deducing which observable events should follow if the hypothesis were true (what Hempel called the test implications of the hypothesis), then conducting an experiment and observing whether or not the test implications occurred.
Following this, I examined the implications of the hypothesis and attempted to better understand some of the anomalies of the age-specific incidence data.
We also discuss this point under implications of the hypothesis.
The paper concludes with a summary of the findings and other implications of the hypothesis.
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