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Predicated on an implication of the central dogma of molecular biology, genomic convergence analysis posits that clinically relevant nucleotide variation should result in detectable cis- and trans-effects in messenger RNA (mRNA) that amalgamate into functional changes in networks and pathways.
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There might be a lack of critical thinking about recommendations and a poor understanding of the practical implications of the central limit theorem.
The clinical implications of the central-acting α2-agonists reveal an unexpected sedative potential that is in part mediated by a proposed vagomimetic potential of these agonists to activate the vagus nerve [ 2].
These and other data suggest a link between the role of diet and the implication of a central role for the keratin 8 (K8) as guardian of the colorectal epithelium.
Neurological implications of cancers of the central and peripheral nervous system, as well as cancers of other systems are described in well-written and well-organised chapters.
The implication of a central mechanism does not mean an absence of peripheral fatigue but seems to confine this type of alteration to a moderate level in the case of ultra-long exercise.
A recent alternative neurological hypothesis proposed by Ethier et al., suggests a possible implication of the immune cells of the central nervous system, i.e. the microglia.
Recently, research stressed the implication of central involvement in ST percept and in ST related distress leading to the conclusion that in most cases the real culprit is in the brain.
A central implication of the RO hypothesis is that sense/antisense encoded fragments should be exhibit both activities.
One implication of linking central bank funding to increases in commercial lending is that risk exposure for both private banks and central banks increases, and policy-makers at the ECB must be willing to demonstrate this kind of risk appetite.
Not surprisingly, many subsequent reports have alluded to the theoretical transcriptional implications of such enzymatic reaction because of the central role that histones play in DNA packaging and epigenetic regulation.
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