In any case, further functional studies are required to unequivocally prove the implication of the candidate gene in controlling the proposed volatile accumulation.
However, we are aware that, given the small sample size for which CGH and transcriptomic data were available, this genomic exploration only provides leads for functional analyses to formally demonstrate the implication of the candidate drivers in GC tumorigenesis.
Although the implication of these candidate genes is only a preliminary finding, and validation by microsatellite analysis in a larger cohort of samples would be required in order to definitively link them with the pathogenesis of NHL, they clearly illustrate the utility of the CHC method for derivation of LOH candidates.
The implication of other candidate genes in melanoma predisposition is supported by less conclusive evidence, such as PALB2, in which a deleterious mutation has been detected in a single individual affected by four kinds of cancer, including melanoma [ 15].
To further explore the implication of amplified/deleted candidate drivers in processes altered in cancer, we determined for each of them a list of positive and negative "transcriptomic neighbors" (i.e. genes whose expression levels displayed R > =0.63 or R = <−0.63 with the expression of the relevant driver over the tumor samples).
Information on protein interactions for genes that contribute to susceptibility of complex diseases may give valuable clues of not only the functional implication of candidate genes but also about additional candidates.
If true, addressing his brother as "Kennard" (not "Dr. Clark") while introducing himself as "Gen. Wesley Clark" (rather than "Wesley" or "Wesley Clark") says a number of things about Clark, the man (and by implication, the candidate) -- and none of it is flattering.
In addition to a demonstrated implication of such candidate genes, family-based segregation and linkage analyses have repeatedly identified the importance of the chromosomal region 5q31-33 in the control of parasite density, with heritability exceeding 40% [7] [11].
The clear implication of candidate Trump's promise to "drain the swamp" was that he would rid Washington of corruption.
The implication was clear: The candidate wasn't challenging herself.
