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Moreover, we excluded from our study both adjuvant-related bother and social/emotional implication of disease progression and obtain health-related HRQOL results with minimal biases.
We enrolled disease-free patients in order to exclude bother related to adjuvant and salvage therapies and avert the social/emotional implication of disease progression.
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5 Implications of disease progression include restrictions in daily activities, reduced work productivity, and diminished quality of life.
While apoptosis has been widely reported in studies of influenza infection, its implication on disease progression has not been well understood.
Aging adversely affects inflammatory processes in the brain, which has important implications in the context of disease progression.
Moreover, it might have important implications for diagnostic evaluation of disease progression and therapeutic efficacy in patients.
These results demonstrate the feasibility of OCT to assess neurodegenerative disease severity in mouse models of neuronal ceroid lipofuscinosis and might have important implications for diagnostic evaluation of disease progression and therapeutic efficacy in patients.
In general, the presented method can be used to perform non-invasive and longitudinal studies in mouse models of neurological diseases and might have important implications for diagnosis and monitoring of disease progression and therapeutic interventions.
The uncertainty of disease progression and the implications for risk to one's own health are compounded by the difficulties of watching a close family member suffer.
Measures of disease progression and the implications of these observations for trial planning and policy are reported separately.
Biomarkers of disease progression are mostly missing.
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