The Electoral Implications of Candidate Ambiguity.
The winning project, Internet venture Politify, combines economic modeling, political analysis and social media to create an interactive political-impact calculator; the site is designed to engage voters around the practical and financial implications of candidates' policy decisions, actions and platforms.
Thus, it is crucial to examine more deeply the implications of candidates' stated faith-based positions, keeping in mind the Constitution's prohibition against religious tests in government.
In addition to a demonstrated implication of such candidate genes, family-based segregation and linkage analyses have repeatedly identified the importance of the chromosomal region 5q31-33 in the control of parasite density, with heritability exceeding 40% [7] [11].
In any case, further functional studies are required to unequivocally prove the implication of the candidate gene in controlling the proposed volatile accumulation.
The implication of other candidate genes in melanoma predisposition is supported by less conclusive evidence, such as PALB2, in which a deleterious mutation has been detected in a single individual affected by four kinds of cancer, including melanoma [ 15].
However, we are aware that, given the small sample size for which CGH and transcriptomic data were available, this genomic exploration only provides leads for functional analyses to formally demonstrate the implication of the candidate drivers in GC tumorigenesis.
Although the implication of these candidate genes is only a preliminary finding, and validation by microsatellite analysis in a larger cohort of samples would be required in order to definitively link them with the pathogenesis of NHL, they clearly illustrate the utility of the CHC method for derivation of LOH candidates.
To further explore the implication of amplified/deleted candidate drivers in processes altered in cancer, we determined for each of them a list of positive and negative "transcriptomic neighbors" (i.e. genes whose expression levels displayed R > =0.63 or R = <−0.63 with the expression of the relevant driver over the tumor samples).
