Results from these experiments implicate the use of aging of dilute multimeric enzymes at the end of freeze-thawing to control the variability in enzyme assays.
CEUS implicates the use of dedicated low mechanical index presets and intravenous administration of a bolus of 2.4 ml of contrast material, containing 8 μl/ml sulphur hexafluoride microbubbles, followed by a 10-ml saline flush; the target lesion is then scanned for the following 3 5 min in order to assess its vascularization.
Taken together, these findings implicate the use of TNKS inhibitors to target the Wnt pathway to combat lung cancer.
New data implicate the use of specific classes of antimicrobial agents in the spread of vancomycin-resistant enterococci (VRE).
Combined studies in humans and poultry have implicated the use of fluoroquinolones in poultry in the emergence of drug resistance (15 – 15 ).
Some studies have implicated the use of HAART among PLWH in decreased locomotor performance as a result of direct adverse effects on the muscle and peripheral neurotoxicity [ 50, 78].
>> Concerning the VEGF family members, overall, these proteins, with the exception of VEGFR-1, presented a high intensity and extension of expression in cancer cells (Fig. 2), which implicated the use of a different cut-off (>5 instead of >2) for the VEGF family in the subsequent analysis.
While materials based on natural ECM have been used to implicate the role of substrate stiffness for cell fate decisions, it is difficult in these matrices to isolate mechanics from other structural parameters.
One study using phosphatase inhibitors have implicated the role of PP2A in the dephosphorylation of Stat3 [42].
These results implicate the prospective use of leptin gene polymorphisms for association studies with different productive and reproductive performances and marker assisted selection (MAS).
Subsequent publications not only described germline mutation in miR-16-1 in two CLL patients (9), but also implicated the potential use of miRNAs as prognostic markers in CLL due to their aberrant expression signatures with respect to IGHV mutation status and TP53 abnormalities (9, 10).
