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The BFA treatment significantly reduced the motility of the MDA-MB-231 cells, thus implicating the integrity of the Golgi in the movement of these cells.
Interestingly, CYP2B6 activity readily produced metabolites of an oxazine EFV analogue (analogue 8), further implicating the integrity of the oxazinone moiety in CYP2B6 metabolism of EFV and not simply the carbonyl oxygen atom.
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That's the fundamental question that the Supreme Court confronts in Luis v. United States--a question that implicates the integrity of the criminal justice system.
Noticeably, pre-incubation with 20 μM nor-BNI 1 h before METH treatment did not cause significant appearance of double-membrane vacuolar structures, nor did treatment alter the integrity of mitochondria, implicating the role of KOR in METH-induced autophagy.
The changes in phenotype, together with the microarray results, implicate the cell wall integrity MAP kinase pathway as a possible mechanism for sensing the low shear microgravity environment.
Furthermore no evidence of compensatory mechanisms was noted, as the protein level and/or localization of key molecules implicated in maintaining the integrity and architecture of myelinated peripheral nerves (e.g., E-cadherin, claudin-1 and -19, Mupp-1, caspr and myelin-P0) appeared to be normal.
Studies of its functional involvement have implicated the homeostasis of cholesterol and phospholipids, synaptic integrity, amyloid metabolism, phosphorylation of tau, accumulation of neurofibrillary tangles and neuronal survival [ 55].
Ribonucleotide accumulation in genomic DNA of RNaseH2null mice implicates the RNase H2 complex in the maintenance of genome integrity.
Each defendant implicated the other.
You have to implicate the audience.
A separate CIA report implicated the KGB.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com