Sentence examples for implicating loss from inspiring English sources

Dysregulation of the normal cell cycle machinery is integrated to the neoplastic process and there is evidence implicating loss of cell cycle control in the development and progression of most human cancers, including pancreatic cancer.

However, despite the convincing evidence implicating loss of function of p53 in breast neoplasia, mutations in the gene occur at a significantly lower frequency than in other common solid tumours.

The SESN1 (6q21) and SESN2 (1p35) loci are frequently deleted in a variety of human cancers [ 1, 22, 23], implicating loss of Sestrins in tumor progression and suggesting that Sestrin-dependent inhibition of TORC1 is critical for suppressing tumorigenesis spurred by age-dependent accumulation of damaged DNA.

Dysregulation of the normal cell-cycle regulatory machinery and of apoptosis mechanisms are integral to the neoplastic process, and there is now compelling evidence implicating loss of cell-cycle control in the development and progression of most human cancers (Sherr, 1996).

Early karyotype/phenotype correlations studies implicated loss of the short arm in growth failure.

Absence of the IIH6 epitope implicates loss of the ligand interaction site on dystroglycan.

Hence, preclinical studies strongly implicate loss of MMR, in particular loss of hMLH1, in overcoming apoptosis by cisplatin.

However, a number of observations have implicated loss of ARE-mediated post-transcriptional regulation in the neoplastic transformation of cells [ 11].

Current evidence implicates loss of intervertebral disc (IVD) matrix consequent upon disc 'degeneration' as a major cause of low back pain [ 1].

While epithelial malignancy is not a common feature of TSC, studies in this laboratory and others have implicated loss of function of TSC1 in bladder tumorigenesis (17– 17).

Copy number analyses have implicated loss of heterozygosity of chromosomal regions 9p, 17p and 21q in the potential development of these tumors [ 17].