We were also able to define these groups according to promoter homology, implicating the participation of promoter-specific binding activity in the coordinated expression of each of these groups and suggesting the existence of additional common transcriptional activators that recognize the specific demethylated promoter sequences of these genes.
It is also notable that the suppression of U32a, U33, and U35a box C/D RNA genes in cells resulted in inhibited accumulation of H2O2-derived reactive oxygen species, thus implicating the participation of these snoRNAs in a common mechanism of cellular response to oxidative stress.
The participation of lysosome pathway implicates the involvement of autophagy pathway as an upstream process of the lysosomal degradation [ 100].
However, the side chain oxygen atoms of this glutamate are oriented away from the catalytic histidine implicating the non-participation of this residue in stabilizing the tautomeric conformation of the histidine.
Outcomes of risks management can be efficient if programs combine multidisciplinary and concerted approaches, including the participation of implicated population and the coordination of national programs.
Although here we have only directly assessed ERK activation as a signaling cascade end point, the participation of upstream signaling repertoires was implicated by our specific inhibitor assays.
Although we cannot at this time rule out the participation of other, untested factors, our findings implicate the stroma as playing a crucial role in the strain-specific differential hormone receptor expression and hormone responsiveness.
The Toll-like receptors (TLRs) have been clearly implicated in maintaining gut homeostasis and in the development of IBD [ 5] although the participation of the whole TLR family in the colonic mucosa from UC patients has not been fully explored.
More recently, evidence for the participation of RNA-binding proteins belonging to the ZFP family has been implicated, while a protein tyrosine phosphatase, TbPTP1, in its active form, has been reported to inhibit the differentiation of BSF to PCF [55].
