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Objectives: An increasing amount of experimental and epidemiological evidence implicates the involvement of oxygen derived radicals in the pathogenesis of cancer development.
Additionally, activated caspase-3 immunoreactivity in both neurons and astrocytes implicates the involvement of the apoptotic pathway in the pathology of these mice.
Increasing evidence further implicates the involvement of HH signaling in oncogenesis and metastatic behavior of colon cancers.
Although we have not examined BLA in neonatal animals here, the age (8 14 days old) at which rats were used in the initial studies by Crozier and Pincus [1] strongly implicates the involvement of the melanopsin system.
This implicates the involvement of TNF-signaling in CCl4-induced hepatic injury and provides a mechanistic explanation for the hepatoprotective effects of Marimastat in both acute, and chronic CCl4-induced hepatic injury.
Other than MGMT, increasing evidence implicates the involvement of other kinds of repair pathways, for example, base excision repair (BER), Fanconi anemia (FA) repair, or double strand break (DSB) repair pathways which are involved in the repair of DNA damage induced by alkylating agents [6] [11].
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These effects, together with the number of signalling molecules produced by the urothelium, in particular ATP, adenosine, and nitric oxide, implicate the involvement of the urothelium in various mechanisms involved in lower urinary tract disorders [ 16].
In humans, early functional MRI studies implicated the involvement of both cortical and subcortical brain regions involving auditory as well as nonauditory structures ([ 5– 8]; see also [ 9, 10] for reviews).
These studies have implicated the involvement of genes encoding one of two types of proteins involved in B uptake and translocation: (1) efflux-type B transporters or (2) members of the major intrinsic protein (MIP) family.
Tapes released by Kuchma's former bodyguard, however, clearly implicated the involvement of government officials.
The results implicate the involvement of 5-HT in neural regulation of response inhibition and re-engagement.
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