Mechanistic studies implicate the function of erbB3 as a major cause of treatment failure in human cancers [ 20].
Using asymmetrically radiolabeled sucrose infused into mature sorghum stems, it was also reported that sucrose movement in mature internodes included an apoplasmic transport step [ 79], implicating the function of sucrose transport proteins.
Here, we summarize some of the recent discoveries in sirtuins biology which clearly implicate the functions of sirtuin proteins in the regulation of premature cellular senescence and accelerated aging.
The foundations of the state providing NATO's second-largest army have become implicated: the functioning of the rule of law, the separation of powers and the impartiality of the judiciary.
Interestingly, an independent RNAi-based knockdown screen showed that Tip60-p400 histone acetyltransferase (HAT) complex proteins, which interact with Myc in ES cells [ 20], also play a crucial role in ES cell identity [ 50], implicating the functions of Myc-interacting proteins in the control of ES cell pluripotency and somatic cell reprogramming.
The presence of TBR1 in stem cells responding to telencephalon injury implicates the normal function of these cells in this region of the brain.
In the brief, McCain and Whitehouse said the case "implicates the effective functioning of American representative democracy".
Although the effects are less clear in humans, there is some genetic evidence that implicates the gain of function 118G polymorphism of OPRM1, the MOR gene, in binge eating disorder (22).
Our study implicates the loss of function of DNA methylation and MeCP2 as a cause of altered pre-mRNA splicing, which could potentially contribute to disease development, a possibility that warrants further investigation.
Here, we summarize the disorders that implicate the digestive function of sucrase-isomaltase as well as the diagnostic and therapeutic strategies utilized to restore normal intestinal function.
