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Mounting evidence implicates a decline in mitochondrial function due to increased opening of the mitochondrial permeability transition pore (mPTP).
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These agents improve the perturbed adipokine secretion and the insulin resistance, thereby further implicating a decline in the activity and level of PPARγ in the pathogenesis of diabetes [ 10, 11].
Oxidative stress-associated damage to biomolecules such as oxidative proteins and DNA damage has been implicated in a decline in functional competence of cerebral cortex [ 11, 72, 83].
A decline in mitochondrial activity has been implicated in multiple degenerative diseases of aging [ 2].
The sustained high levels of IIV and Nosema peptides that occurred in the observation colony as the frequency of forager flights declined strongly implicates an IIV-6-like virus and Nosema as co-factors in CCD, since forager bee activity declined as pathogen loads peaked.
However, his statement implicates a broader meaning.
The rapid onset implicates a neural mechanism.
Habitat loss, silting of streams, pollution and disease have all been implicated in the decline and a captive breeding programme at Saint Louis Zoo has been successfully established.
Reduced availability of NO, important for angiogenesis and maintenance of endothelial integrity, together with increased generation of O2−*, a marker of inflammation and mediator of atherosclerosis, are implicated in decline of vascular function in diabetes [4] [7].
While tamoxifen has been implicated in decline in cognitive function (Paganini-Hill and Clark, 2000), these data do not come from double-blind randomised placebo-controlled trials, and so the issue remains controversial.
Highly pathogenic infectious agents have been implicated in the decline and extirpation of a considerable number of populations (1 – 3 ).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com