Recent studies have implicated a class of immune system receptors called Toll-like receptors (TLRs) in the synergistic activation of B cells by BCR and TLR signaling.
As the curator of data implicating a drug class as an inactivator of a key protein in both AIDS and cancer, Montgomery should be willing to share his results with other scientists.
The association between HLA-DRB1 SE and ACPA positivity implicates a role for MHC class II-dependent CD4+ T cell activation in ACPA+ RA [ 22].
Now some of the first detailed evidence implicating organotins, a class of persistent compounds containing at least one tin carbon bond, has been published in the September 2006 Molecular Endocrinology.
On average, only 5.5% of ORFans in a genome (range, 2.1% to 12.3%) have protein functions assigned by the annotation approach used in the Protein Clusters database (which may implicate a very specific class of enzyme-catalyzed reaction, or only a particular family of functions).
These results indicate the involvement of PI3-Kδ in the OC culture system, consistent with a previous report which implicated a critical role of class IA PI3-K in OC formation by demonstrating that OC progenitor cells from mice lacking p85α, a regulatory subunit of class IA PI3-K, showed impaired growth and differentiation [ 23].
Our studies have not implicated any class I HDACs in the pathogenesis of PKD1.
Sob story Reprints Related items Gulf-war syndrome: The fog of warAug 21st 2003In recent years evidence has begun to implicate exposure to a class of chemicals known as acetylcholinesterase inhibitors.
Ligand binding sites and key catalytic residues are structurally conserved, strongly implicating LsrF as a class I aldolase.
Key catalytic residues in these class I aldolases are structurally conserved in LsrF, and both P-AI-2 analogues bind LsrF in the canonical aldolase active site, strongly implicating LsrF as a class I aldolase.
