While induction of pro-apoptotic genes is expected upon treatment with chemotherapeutics, the down-regulation of genes implicated in apoptosis upon exposure to cisplatin and topotecan could be indicative for some compensatory mechanisms, linked to drugs-induced cell death [ 20].
Neither macrophage nor endothelial cluster contains TIE2, which has been implicated, based largely upon in vitro studies, in tumour-associated angiogenesis and regulatory T cell production [ 65, 66].
Open image in new window Figure 4 Autophagy is implicated in cell recovery upon Apaf1 inhibition.
Statistical significance was assessed by means of two-tailed Student's t-test (*P < 0.05; ***P < 0.001) Open image in new window Figure 5 Autophagy is implicated in cell recovery upon Apaf1 inhibition.
Glyphosate and Roundup, the herbicides which GE crops depend upon, are implicated in numerous adverse health impacts in human beings.
Furthermore, we highlight putative implications of the loss of distinct donor cell signature genes and the activation and/or retention of genes implicated in development processes upon cellular reprogramming.
Aurora B and Plk1 have been implicated in chromosome congression upon knockdown of B56 subunits (Foley et al., 2011).
Previously, an autocrine TNF α loop has been implicated to mediate apoptosis upon single agent treatment with cytotoxic concentrations of Smac mimetics that stimulate the production of TNF α, thereby initiating TNFR1-mediated cell death.
Differential expression analysis of genes implicated to be regulated upon activation of the Raf-kinase (Napoli et al., 2012) revealed no transcriptional alterations in MAL-overexpressing Schwann cells, also demonstrating that the ERK pathway seems not to be affected by MAL overexpression (Supplementary Table 4).
