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It also seems to be implicated, together with SP1 and SP3, on the establishment or reactivation of varicella-zoster virus latency [233].
However, IR-A shows considerably higher affinity for IGF-1 and particularly for IGF-2 than IR-B [16], and has been implicated together with the IGF1R in malignant transformation [17], [18].
BoNT/A targets and cleaves the synaptosomal-associated protein of molecular weight 25K (SNAP-25), a protein associated predominantly with the plasma membrane, and which is implicated, together with syntaxin and the vesicular protein VAMP/synaptobrevin, in the fusion machinery of catecholamine-containing large dense core granules [16], [17].
Barley NP1 has been reported to be localized to the cell wall of nucellar cell types [ 19], while rice REP-2 has been implicated, together with REP-1, in storage protein degradation [ 20].
Thus in Australia, weedy Hordeum species have been implicated together with volunteer wheat plants as off-season (over-summering) hosts for Puccinia striiformis allowing this pathogen, that has no protected spore stage, to survive for the several months between maturity of one year's wheat crop and emergence of the next (Wellings 2007).
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However, many genes that have been implicated function together in pathways and interact with one another [Asbell et al., 2005; Bao et al., 2012; Cho et al., 2007; Chong et al., 2009; Martinez and de Iongh, 2010].
The involvement of Sp1 in the regulation of many genes currently implicated in schizophrenia, together with the duality of Sp1 having a ubiquitous as well as environmental and intracellular specific signal regulated transcriptional activities, concur with the multi gene abnormality and symptom heterogeneity observed in schizophrenia.
The supramarginal gyrus and BA 44 are together implicated in a dorsal phonological working memory system (Vigneau et al., 2006; Price, 2012).
Urine insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP-2), both inducers of G1 cell cycle arrest, a key mechanism implicated in AKI, together demonstrated an AUC of 0.80 (0.76 and 0.79 alone).
Cocaine and opioids together were implicated in four of the seven deaths attributed to accidental drug overdose (see online supplementary table S1).
Two sequences clustered within the third class, which brought together proteins implicated in neuro/developmental functions, such as acetylcholinesterases and other non-catalytic proteins.
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