Sentence examples for implicated to mediate from inspiring English sources

These functions of CD38 as ectoenzyme and receptor have been implicated to mediate the humoral and innate immune response of lymphoid and myeloid lineage cells [5], [9].

Inhibitory KIR2D receptors are divided into two families based on their specificities for different HLA-C allotypes and residue 80 of HLA-C has been implicated to mediate this specificity [20].

The observed antioxidant activity is significant because free radicals have been implicated to mediate in stress, NSAID and H. Pylori induced gastric ulcers [ 5, 29].

We also monitored two effectors that have been implicated to mediate Ret-regulated cell proliferation and differentiation, i.e. Akt and Erk (Airaksinen and Saarma, 2002; Asai et al., 2006; Hayashi et al., 2000; Mograbi et al., 2001).

Previously, an autocrine TNF α loop has been implicated to mediate apoptosis upon single agent treatment with cytotoxic concentrations of Smac mimetics that stimulate the production of TNF α, thereby initiating TNFR1-mediated cell death.

Although an autocrine/paracrine TNF α loop has been implicated to mediate Smac mimetic-induced cell death, little is yet known about additional factors that determine sensitivity of cancer cells to Smac mimetic-triggered apoptosis.

Furthermore, membrane localization of ERα and ERβ has been demonstrated in glia cells in different brain regions [43], [45], [47], [48], and glia cells have also been implicated to participate in mediating estrogen neuroprotection via the release of growth factors and neuroactive steroids [49], [50], [51].

Various IRES trans acting factors or ITAFs have been implicated to have role in mediating internal initiation of translation.

As promoter motifs have been implicated in helping to mediate specific enhancer-promoter interactions [ 10, 16- 19], these differences are likely to represent one of the mechanisms used by the genome to prevent inappropriate gene activation by nearby CRMs.

Midbrain dopaminergic neurons, especially in the mesolimbic system has been implicated as major candidates to mediate incentive salience in the natural reward pathway.

The absence of these phosphorylations in the BVr- enzyme though conceivable in view of its lesser activity was surprising to account for its continued inhibition by rapamycin in the context of substantial evidence implicating these phosphorylations, especially T412 to mediate the inhibitory effects of the drug [ 11, 15].