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Estrogen has been implicated to induce tumor promotion and/or progression by enhancing cell proliferation [ 16].
Moreover, severe environmental pollutants have been implicated to induce hepatic inflammation [ 27– 29].
Similar to most other polyphenols, resveratrol is suggested to possess intrinsic anti-oxidant capacity, but it is also implicated to induce the expression of a number of anti-oxidant enzymes, with probably both mechanisms contributing to an overall reduction in oxidative stress [ 32].
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Whilst no studies have demonstrated a role of MTA2 or the effects of histone acetylation in human implantation, the Rho signalling pathway has been implicated to have a role in inducing human trophoblast invasion and migration (Saso et al., 2012) The downregulation of MTA2 by miR-661, may therefore inhibit activation of MTA2 target genes, such as Rho, which are required for embryo implantation.
Interestingly, CaMKIIδB has been even implicated to suppress apoptosis by inducing the anti-apoptotic proteins Bcl-2 and HSP70 (Little et al, 2009) and to induce pathological cardiac remodeling by phosphorylation of histone deacetylase 4 (HDAC4) (Backs et al, 2006; Zhang et al, 2007).
ODQ (10 µM) and KT-5823 (1 µM) significantly reduced the ability of DTT to induce tube formation, implicating the guanylyl cyclase-PKG pathway in this process (Fig. 5C and D).
In order to determine whether ABA was implicated in inducing the stressed esk1 state, ABA contents were measured in rosettes of wild type and two esk1 mutants (esk1-4 and esk1-5) submitted or not to mild drought (Figure 1) and compared to the ABA-deficient mutant aba3-1, affected in the sulfuration of the molybdenum cofactor required for the last steps of ABA biosynthesis [17], [18].
Next we examined whether HSF1 over-expression increases markers of epithelial-to-mesenchymal transition (EMT), which has been implicated in inducing the CSC phenotype [ 10].
Myb transcription factors have been implicated in inducing the stress response in plants in response to various abiotic stresses including phosphate stress [ 37] and asian soybean rust [ 38].
Nonetheless, confirmatory qPCR analyses for selected genes that previously had been suggested to be implicated in ventilator induced lung injury [36 38] were significantly higher in the HVT/LPEEP group.
ESAT-6 is a secreted protein of Mtb, which is absent in BCG but has been implicated in inducing protective immunity against Mtb.
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