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Co-secretion of GLP1 and GLP2 is implicated to decrease circulatory LPS and cytokines.
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The requirement for cAMP/PKA to decrease Sost thus implicated either EP2 or EP4 receptor.
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Though aging has been implicated as a factor contributing to decreased ascorbic acid uptake in earlier studies, [ 13] and all of our patients were between the ages of 45 and 78, it is important to note that aging was not the cause of our particular findings.
The mechanisms implicated include decreased thirst, which leads to insufficient water intake and impaired renal response to ADH, which leads to excessive loss of water in the urine.
Such policies may be directly implicated in decreasing the probability of failure to a large degree while also decreasing slightly the probability of higher success.
A wide variety of pathways have been implicated, including decreased topoisomerase II expression, reduced sensitivity to apoptosis via alterations in the expression of Bcl2 family members and the efflux of chemotherapeutic agents from cancer cells [ 76].
Increased expression of anti-apoptotic factors such as Bcl-XL, which affects the intrinsic pathway, have been implicated in decreased apoptosis.
The proper functioning of this complex tissue involves adaptation to a host of cellular and environmental stressors over time, and cumulative long-term detrimental effects of oxidative stress have been implicated in decreased aqueous humor outflow.
While IL-1β and IL-6 have been strongly implicated in decreased NSPC proliferation and neurogenesis [18], [19], others like TNF-α exert dual effects depending on the receptor types involved.
Metformin and proton pump inhibitors have been implicated in decreasing levels of vitamin B12 independently.
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