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These defense-response (DR) genes are implicated to contribute to quantitative and broad-spectrum resistance to pathogens (Faris et al. 1999; Freialdenhoven et al. 1996; Liu et al. 2004; Lu et al. 2004; Ramalingam et al. 2003; Wen et al. 2003).
A potential loss of metastasis suppressor has been implicated to contribute to this pathway.
DR6 also mediates oligodendrocyte cell death during development, and oligodendrocytes have been recently implicated to contribute to motor neuron disease in SOD1G93A mice.
Primary glioblastoma cultures have previously been described and glioblastoma stem-like cells, implicated to contribute to glioblastoma progression due to their increased cell death resistance, were characterized by Nestin staining and CD133 expression (Supplementary Figures 2A and B).
Indirect effects through accelerating chronic inflammation, oxidative stress, and metabolic abnormalities (e.g. hyperglycemia, dyslipidemia, and elevated blood pressure) have been implicated to contribute to endothelial dysfunction, thereby enhancing atherosclerotic cardiovascular disease [ 17, 35].
Fat mass has been suggested to be important in survival of the patient (Kalantar-Zadeh et al, 2007) whereas muscle mass has been implicated to contribute specifically to the quality of life of the patient (Muscaritoli et al, 2004).
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Nonetheless, most of these kinases have been implicated to also contribute to an inflammatory response.
Therefore it is not surprising that changes in neuromelanin have been implicated to be important, contributing to the selective vulnerability of dopaminergic neurons in PD.
Previous studies in animal models as well as human epileptic brain tissue revealed a remarkably diverse pattern of gene expression implicating epigenetic changes to contribute to disease progression.
Many of the proteins identified have been implicated in pathways thought to contribute to the physiologic homeostasis of cartilage, synovial tissue, and SF.
Interestingly, increased expression of many of these products (IL-1β, TNFα, and Cox-2) has been implicated in previous studies to contribute to mammary hyperplasia and tumorigenesis [ 29– 31].
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