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A dozen employees have been implicated since the 12 April argument became public.
First, it appears to be too sweeping: research with adult stem cells and non-human animal stem cells, as well as general research in genetics, embryology, and cell biology could be implicated, since all of this research might advance our understanding of HESCs and result in increased demand for them.
However, class II HDACs (e.g., HDAC6) are also implicated since SAHA was also effective.
The VRK1 downregulation is also independent of a proteasome mediated pathway; this mechanism is insensitive to proteasome inhibitors, and hdm2/mdm2 is not implicated since it is also functional in mdm2 deficient cells [12].
We also provide evidence that in this experimental setting the p27/RhoA interaction is not implicated since no direct binding between the two proteins was detectable, even after overexpression of both proteins (Figure S6A).
PI3K and Akt activation is implicated since L. pneumophila entry into macrophages is inhibited by two structurally distinct inhibitors of PI3K activity, wortmannin and LY294002, in a dose-dependent fashion.
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She also implicated antibiotics, since they can decimate protective, good bacteria along with the bad.
Mr. Dingstad said that two of the priests implicated had since died, and that he did not know the whereabouts or status of the others.
Young or old, bigoted or tolerant, liberal or conservative — everyone is equally implicated here, since everyone is predisposed to the same, or at least analogous, mental habits and has access to the same technological tools.
Generally, large sample size is required for genetic association studies of single gene and disease susceptibility depending on the prevalence of the implicated polymorphism, since susceptibility of specific disease is always determined by numbers of genes [37].
EBV has been implicated in carcinogenesis since the discovery of its implication in Burkitt's lymphoma in sub-Saharan Africa in the 1960s [ 9].
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