A number of studies have implicated relationships between such SVs and human phenotypes including diseases such as cancer susceptibility [ 1], mental disorders [ 2], metabolic disorders [ 3], and some types of intractable diseases [ 4- 6].
26 Consequently, the financial situation implicated the relationship of the patients with the healthcare professionals.
Although these association are quite modest, the largest representing a mere 20 g sucrose/day per allele which corresponds roughly to 7 pieces of sugar or about one can of soda, they still implicate a relationship between GHRL genetics, sucrose and alcohol consumption, specifically in males.
Several lines of evidence implicate a relationship between attention-deficit hyperactivity disorder (ADHD), circadian rythmicity and sleeping disturbances.
However, the rare instances of multiple associations for individual SNPs implicate a relationship between the targeted genes (Supplementary file 2).
14– 16 While a few studies demonstrate a link between MBS and EDs, 17– 19 there are also some studies implicating a relationship between EDs and anxiety.
Emerging evidence strongly implicates a relationship between glutamate, NMDA activation and reactive nitrogen species in the pathogenesis of MS and the related model, EAE [1,9,46].
From [ 25], we know that APP is a key gene related to Alzheimer disease (AD), and it implicates the relationship between neurodegenerative diseases and stroke.
Several lines of evidence implicate a relationship between induction of SODs in tumour cells and reversion of neoplastic transformation or loss of the malignant phenotype including metastatic property.
Similarly, a miRNA expression profiling study of human metastatic cancers and paired primary tumors found miR203 to be consistently underexpressed in the metastatic tissue, further implicating a relationship between ZEB1 regulation of miR203 and tumor invasiveness and metastasis.
