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Today, it is well-established that lymphomas can evolve due to both 'cell-intrinsic' factors (e.g. acquired genomic aberrations) and 'cell-extrinsic' factors (e.g. microenvironmental stimuli), although for most lymphoma subtypes the precise implicated mechanisms remain to be elucidated.
Further exploration of the implicated mechanisms of such an involvement may shed new light on the role of bile acids in intestinal and biliary inflammation, which could ultimately have therapeutic implications.
Such studies will be facilitated by knowledge of implicated mechanisms of action for most of the compounds in the JHDL.
The oncoprotective role of food-derived polyphenol antioxidants has been described but the implicated mechanisms are not yet clear.
26 In this study, the impact of differences in optimal medication, one of the implicated mechanisms of the obesity paradox, was explored.
Implicated mechanisms include regulation of proliferation, EMT, metastasis and chemoresistance (Hughes, 2009; Meng et al, 2009; Kannan et al, 2011; Zage et al, 2011; Ueo et al, 2012).
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Pulmonary hypertension causing right heart strain, leading to release of BNP from the right ventricular myocardium has been the most commonly implicated mechanism [21, 22].
Pulmonary hypertension causing right heart strain, leading to release of BNP from the right ventricular myocardium has been the most commonly implicated mechanism [ 21, 22].
Hence, variations among cell types in this type of modification implicates mechanisms different than those involved in focal peak dynamics.
Th2 activation and eosinophilia implicated immunological mechanisms.
The N-methyl-d-aspartate receptor (NMDAR) has been strongly implicated in mechanisms of persistent pain states.
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