Plants have a family of caspase-related proteins, designated as metacaspases, and numerous studies have implicated caspase-like proteases in the control of cell death activation in plants [ 22].
The differentially expressed genes also broadly implicated receptor-like kinases, which were down-regulated in the resistant lines, and other growth and defense genes, which were up-regulated in resistant lines.
Recent circumstantial evidence has implicated Insulin-like growth factor II in the genesis of several tumour types, notably developmental tumours (Scott et al., 1985; Schofield & Tate, 1987; Wilkins et al., 1989).
IL-2 is a T-cell growth factor produced during the primary immune response which declines upon differentiation to be replaced by Th1-like (promotes cellular immunity), Th2-like (promotes humoral immunity), Th17-like (implicated in autoimmune disease) and Th22 (implicated in inflammatory skin disease) cytokines 32– 32.
This could represent a sirtuin-independent pathway central to the control of lifespan implicating insulin-like signalling through the P13K/protein kinase B cascade and the downstream FOXOs.
These analyses implicate trypsin-like serine proteases, berberine-bridge enzymes, carbonic anhydrases, small cysteine-rich proteins and repeat-containing proteins as novel candidate virulence factors.
While Andersen, in short, has earned its fate, other big accounting firms have been implicated in Enron-like cases as well.
Finally, these studies demonstrated that NE is implicated in emphysema-like structural lung damage characteristic of βENaC-Tg mice [35, 57].
Signaling molecules such as PKC and PI3K have been implicated in anxiety-like behavior as well as learning and memory processes.
