We therefore hypothesized that P-Rex could act as an intermediary for the PI3K-dependent activation of Rac – two enzymes which have been implicated in late phase LTP in the hippocampus – and may thereby play a role in cerebellar LTP.
Additionally, several gene polymorphism have previously been implicated in late radiation-induced tissue damage (Awad et al, 1988; El-Gamel et al, 1999; Grainger et al, 1999; Quarmby et al, 2003; Andreassen et al, 2005; De Ruyck et al, 2005, 2006; Brem et al, 2006), and TGFβ1 and Hyl1 are induced following exposure to ionising radiation (Anscher et al, 1997; Martin et al, 1997).
Taken together, these data demonstrate the localization of the Nef:MHC-I complex within Rab7 positive late endosomes, thereby implicating the late endosome in the re-routing of MHC-I away from the plasma membrane.
To see whether the same held for other genes thought to protect against cognitive decline, the researchers examined the 1000 Genomes Project for variants of a gene called APOE, which has been implicated in late-onset Alzheimer's.
TGF- β expression by prostate epithelium is negatively regulated by androgen [ 61], and this factor appears to be necessary for apoptosis in response to low androgen [ 22]. bFGF produced by the stroma in response to androgens increases prostatic bcl-2 [ 22], an important anti-apoptosis protein that has also been implicated in late-stage prostate cancer progression [ 30].
Src non-receptor kinases have been implicated in events late in tumor progression.
The mutual fund industry is now waiting to learn the extent to which fund companies are implicated in such late trading.
Objective: Hemodynamics has been implicated in the late failure of arterial bypass grafts, which frequently occurs at the distal anastomosis site.
Several factors were implicated in CAST: late development of ischaemia, congestive heart failure and accumulation of the drug to toxic levels.
This implicated that the late luminal loss became negligible and the prevention of repeat revascularization was significantly improved compared to that with the BMS.
