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Recently, SIRT2 has been implicated in the suppression of glioma formation (Li et al., 2013).
The let-7 miRNA family has also been implicated in the suppression of non-small cell lung tumor development [13] and colon cancer [13], [39].
Moreover, the interaction of MV nucleoprotein with Fcγ receptor on antigen-presenting cells is implicated in the suppression of cell-mediated responses, [17], [18], [19] and in the induction of the T regulatory immune response, following a chronic exposure [20].
Unlike Th1-mediated cytokines such as interferon-gamma that promote the killing of infected cells, regulatory cytokines including interleukin-10 have been implicated in the suppression of in vitro antigen-specific cellular immune responses in tuberculosis.
As the induction of Jdp2 may be implicated in the suppression of IFN-β and other cytokines up-regulated by L. acidophilus NCFM, but down-regulated by B. bifidum Z9, we hypothesized that the MAP kinases p38 and JNK, but not ERK, are involved in the expression of these cytokines.
ZNF342 has been indirectly implicated in the suppression of gliomas.
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Suppression of cdc25A is implicated in the inhibition of tumour growth-promoting MAPK activity (Wang et al, 2008).
NK cells have been implicated before in the suppression of GvHD by two mechanisms: either by direct killing of donor T cells, which are activated by alloantigens and may upregulate ligands for NK-cell receptors DNAM-1 and NKG2D [ 16, 17], or by killing host DCs hence inhibiting donor T-cell proliferation [ 2].
The significantly differentially regulated miRNAs are implicated in the activation or suppression of cellular proliferation and stem cell maintenance, which are required during the repair of the damaged lungs.
The aMFG may select processes (i.e., perceptual cues) congruent with the validated belief; this region has been implicated in the enhancement and suppression of task-relevant and task-irrelevant processes, respectively (Sakai and Passingham 2003; Sugiura et al. 2007).
As HIF-1 has been implicated in transcriptional suppression of Bim and Bid expression in several systems, we examined the HIF-1 protein levels in HTLV-1-Tax-expressing T-cell lines.
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