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The Hariri investigation has been a central point of contention for Syria — which was implicated in the initial reports — and its allies in the Lebanese opposition.
These findings suggest that the up-regulation of NR2B subunits during chronic ethanol exposure may be implicated in the initial development of physical dependence on ethanol.
Plasmepsin-2 is a malarial aspartic proteinase that has been implicated in the initial steps of hemoglobin degradation in parasites and thus represents an attractive antimalarial target.
Both ACE2 and ZPBP2 have been implicated in the initial binding of the sperm acrosome to ZP [35], [36].
This phenomenon was not observed for other chromosomes implicated in the initial linkage studies (i.e., chromosomes 14 and 19).
It is thus possible that like for SHP in Arabidopsis, the rose ortholog of SHP may not be implicated in the initial specification of stamen identity.
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Recently, several miRNAs have been implicated in regulating the initial step in epithelial-mesenchymal transition (EMT).
Noticeable DNA synthesis by reverse transcription, which precedes DNA polymerase-dependent DNA replication in mouse pronuclei [ 27], could be the first phase of DNA replication and serve as the epigenetic mechanism implicated in the establishment of the initial replication timing program and chromatin architecture.
Early endosomes constitute the initial compartment implicated in the endocytosis and sorting of cell surface cargo15,27.
Wnt signaling has been implicated in the regulation of early patterning and initial outgrowth of the vertebrate limb bud [1] [4].
Indeed, even the initial candidate gene (MYH9) implicated in the first two AM studies, has since been superseded by a more statistically and biologically plausible gene (APOL1), though it has been the AM approaches which focused attention to the chromosome 22 region containing these genes in the first place[ 13, 14].
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